Bioinformatics: Life Sciences on Your Computer

Week 1: Biological Databases

·         Database Structure

·         Searching PubMed

·         The NCBI Public Sequence Database

·         Sequence Retrieval

Week 2 - BLAST and Sequence Alignment

·         Pairwise Sequence Alignment

·         BLAST, Database Searches

·         Assessing Homology

Week 3 – Protein Bioinformatics

·         Determining Molecular Weight, Isoelectric Point

·         Predicting Secondary Structure

·         The PDB Database

·         Prosite Domain searches

·         Predicting Cellular Localization

Week 4 – Prokaryotic Genomes

·         Bacterial Gene Prediction

·         Prokaryotic Gene Structure

·         Viruses

Week 5 – Eukaryotic Genomes, Human Variation

·         Eukaryotic Gene Structure

·         Ensembl Database

·         Single Nucleotide Polymorphisms

·         DNA Fingerprinting